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COVID-19 Scan for Nov 03, 2022

Omicron mRNA vaccine efficacy decrease, extra fleeting in youngsters than teenagers

COVID-19 vaccination of kids in Qatar was tied to low to modest, quickly waning safety in opposition to an infection with the Omicron variant, however teenagers had barely extra sturdy, longer-lasting immunity, suggests a examine printed yesterday within the New England Journal of Medication (NEJM).

A group led by Weill Cornell Medication-Qatar researchers used nationwide databases and fast antigen check outcomes from healthcare amenities beginning on Jan 5, 2022, to guage the efficacy of two doses of the Pfizer/BioNTech mRNA COVID-19 vaccine in youngsters aged 5 to 11 years amid Omicron predominance and in adolescents aged 12 to 17 earlier than and through Omicron.

In Qatar, adolescents have been vaccinated beginning in February 2021, adopted by youngsters aged 5 to 11 a 12 months later. Median follow-up was 69 days in youngsters and about 44 and 156 days earlier than and through Omicron in adolescents.

Vaccine effectiveness (VE) of the 10-microgram (μg) main collection in 37,456 youngsters in opposition to an infection was 25.7% (95% confidence interval [CI], 10.0% to 38.6%). VE was strongest instantly after the second dose (49.6%; 95% CI, 28.5% to 64.5%) however fell to a statistically insignificant 11.0% (95% CI, −26.8% to 37.5%) after 3 months.

Amongst youngsters 5 to 7 years, VE was 46.3% (95% CI, 21.5% to 63.3%), whereas it was 16.6% (95% CI, −4.2% to 33.2%) amongst these aged 8 to 11.

VE of two 30-μg vaccine doses in adolescents was 30.6% (95% CI, 26.9% to 34.1%), though many had been vaccinated months earlier. VE was 35.6% (95% CI, 31.2% to 39.6%) amongst adolescents 12 to 14 years and 20.9% (95% CI, 13.8% to 27.4%) amongst older teenagers.

Earlier than Omicron, VE amongst 46,634 adolescents was 87.6% (95% CI, 84.0% to 90.4%) and waned slowly after dose 2. Amid Omicron, VE amongst 35,806 adolescents was 30.6% (95% CI, 26.9% to 34.1%). The authors stated the extra sturdy response in adolescents might be because of the bigger antigen dose.

“Our findings counsel the necessity to rethink the worth and techniques of vaccinating wholesome youngsters within the omicron period with using presently accessible vaccines,” they wrote.
Nov 2 NEJM study


Report: COVID-19 probably unfold via flooring, partitions of quarantine resort

The Omicron SARS-CoV-2 variant was probably transmitted via the flooring and partitions of a quarantine resort in Taiwan in December 2021, including to a big physique of proof that aerosol transmission performs a big position in outbreaks and clusters, based on a report yesterday in Rising Infectious Illnesses.

Taiwan required inbound worldwide vacationers to quarantine in motels for 7 to 14 days following a damaging polymerase chain response (PCR) check earlier than air journey to the island. Within the weeks previous the Lunar New 12 months celebrations of 2022, such motels have been in excessive demand, and lots of business motels transformed to quarantine motels.

The report particulars three case-patients who lived in nonadjacent rooms on totally different flooring of the quarantine resort within the final week of December of 2022, and had no direct contact throughout their keep. All three examined damaging for the virus inside 72 hours of boarding flights to Taiwan, however examined constructive on PCR assessments whereas staying on the resort.

The case-patients traveled from China, New York, and Japan, respectively, and the authors deduced that the traveler from New York probably had an rising case of COVID-19 because of the Omicron pressure on the time of journey.

Outdated tunnels and air conditioner models have been discovered to transmit aerosols all through the resort. A small-scale tracer-case experiment confirmed a number of air leaks within the constructing, enough to unfold virus aerosols.

“Within the setting of under-ventilated indoor environments with recirculated air con techniques, the exhaled aerosol may stay suspended for a chronic interval and disperse throughout an extended vary,” the authors concluded. “It’s believable, then, {that a} excessive focus of virus-laden aerosol may need amassed in a poorly ventilated room and may need been transported by the airflow throughout totally different rooms via the structural defects.”
Nov 2 Emerg Infect Dis


Pfizer and BioNTech begin medical trial of flu-COVID combo vaccine

Pfizer and BioNTech at the moment introduced the launch of a section 1 medical trial to evaluate the security, tolerability, and immunogenicity of its candidate mixture mRNA vaccine that targets influenza and COVID-19.

The vaccine—given as a single dose— combines Pfizer’s investigational quadrivalent mRNA flu vaccine, which is in section 3 trials, with the up to date COVID-19 booster that targets the unique SARS-CoV-2 virus plus BA.4/BA.5 Omicron subvariants from Pfizer and BioNTech.

Ugur Sahin, MD, BioNTech’s cofounder and chief government officer, stated the objective is to offer folks with an environment friendly solution to shield in opposition to two extreme respiratory ailments that contain evolving viruses that require tailored vaccines. “The info may also present us with extra insights on the potential of mRNA vaccines addressing multiple pathogen. It will assist us to additional develop our infectious illness pipeline to ship on affected person centric vaccination approaches,” he stated.

The trial is underneath means in america and has a objective of enrolling 180 wholesome adults ages 18 via 64. Members shall be adopted for six months. The primary participant was immunized this week.
Nov 3 BioNTech press release

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